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Article

Evaluation of musculoskeletal phenotype of the G608G progeria mouse model with lonafarnib, pravastatin, and zoledronic acid as treatment groups.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2020

Cubria Maria B, Suarez Sebastian, Masoudi Aidin, Oftadeh Ramin, Kamalapathy Pramod, DuBose Amanda, Erdos Michael R, Cabral Wayne A, Karim Lamya, Collins Francis S, Snyder Brian D, Nazarian Ara

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a uniformly fatal condition that is especially prevalent in skin, cardiovascular, and musculoskeletal systems. A wide gap exists between our knowledge of the disease and a promising treatment or cure. The aim of this study was to first characterize the musculoskeletal phenotype of the homozygous G608G BAC-transgenic progeria mouse model, and to determine the...

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Identifiers

PMID: 32404427
DOI: 10.1073/pnas.1906713117
PMCID: PMC7275760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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