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Computational Insights into the Allosteric Modulation of a Phthalate-Degrading Hydrolase by Distal Mutations.

Biomolecules - 26 Feb 2023

Xu Ran, Bao Yiqiong, Li Mengrong, Zhang Yan, Xi Lili, Guo Jingjing

Abstract excerpt

Phthalate esters (PAEs) are a ubiquitous kind of environmental endocrine that disrupt chemicals, causing environmental and health issues. EstJ6 is an effective phthalate-degrading hydrolase, and its mutant with a combination of three non-conservative distal mutations has an improved activity against PAEs with unknown molecular mechanisms. Herein, we attempt to fill the significant gap between distal mutations and...

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PMID: 36979378
DOI: 10.3390/biom13030443
PMCID: PMC10046322

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