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Article

Decoding CTCs in osteosarcoma: the molecular journey from initial tumor to metastasis.

Scientific reports - 3 Apr 2026

Di Gangi Alessandro, Morelli Mariangela, Ipponi Edoardo, Catena Fabrizio, Coccoli Luca, Gaeta Raffaele, Aretini Paolo, Menicagli Michele, Franchi Alessandro, Palmini Gaia, Casazza Gabriella, Andreani Lorenzo, Iantomasi Teresa, Brandi Maria Luisa, Mazzanti Chiara Maria, Lessi Francesca

Abstract excerpt

Metastatic relapse remains the main cause of treatment failure in pediatric osteosarcoma (OS), as conventional imaging often misses minimal residual or low-burden disease. Circulating tumor cells (CTCs) represent a promising non-invasive biomarker for monitoring tumor progression and heterogeneity. We developed an integrated workflow to isolate, enrich, and molecularly characterize CTCs from six pediatric OS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41927850
DOI: 10.1038/s41598-026-47094-5
PMCID: PMC13194890

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