Site-specific methylation of SRSF2P95H by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrome.

doi:10.1126/scitranslmed.adv1065

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Article

Site-specific methylation of SRSF2P95H by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrome.

Science translational medicine - 1 Apr 2026

Li Zi-Juan, Zhao Mu-Ying, Wang Roujia, Liu Na, Hu Cheng-Long, Chang Binhe, Hu Fang, Li Xi-Ya, Xu Chun-Hui, Liu Ping, Chen Bing-Yi, Chen Shu-Bei, Wang Yong, Li Qi-Jing, Xue Bu-Sheng, Deng Chuhan, Chen Xinchi, Ren Yiyi, Jia-Cheng Jin, Yan Xiao, Zhang Yuanliang, Gale Robert Peter, Fu Jianfei, Zhang Qun-Ling, Wang Xiaoning, Huang Qiuhua, Liu Yan, Qiu Ju, Qin Jun, Ye Xueshi, Zhang Jin, Liang Yang, Chen Zhu, Chen Sai-Juan, He Peng-Cheng, Chang Chun-Kang, Sun Xiao-Jian, Wang Lan

Abstract excerpt

Patients with myelodysplastic syndrome (MDS) harboring SRSF2 (serine and arginine rich splicing factor 2) mutations exhibit poor prognosis and aberrant inflammatory activation, underscoring an urgent need for therapies. Here, we reveal that low messenger RNA expression of SETD2 (SET domain containing 2) in hematopoietic stem and progenitor cells (HSPCs) from patients with MDS carrying SRSF2P95 mutations...

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Share to Hematopoietic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone-Lysine N-Methyltransferase

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Share to Mice, Inbred C57BL

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Share to Myeloid-Derived Suppressor Cells

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Source

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Identifiers

PMID: 41920970
DOI: 10.1126/scitranslmed.adv1065

Genes

SETD2
CEACAM1
SET
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Site-specific methylation of SRSF2P95H by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrome.PMID 41920970Read ↗

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