Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Graph statistics theory of individualized quantitative genetics under haplotype-resolved genome assembly.

Proceedings of the National Academy of Sciences of the United States of America - 7 Apr 2026

Sun Lidan, Bian Yangyang, Yang Dengcheng, Miao Runtian, Meng Yihan, Che Jincan, Li Ziwei, Li Zimo, Wang Haoning, Wu Shuang, Meng Juan, Wang Yu, Griffin Christopher, Yau Shing-Tung, Wu Rongling

Abstract excerpt

Quantitative genetics is essential for genetic dissection of complex traits, yet the existing theory fails to illustrate a comprehensive landscape of genetic control mechanisms driving phenotypic variation and evolution. Here, we develop a statistical approach to assemble all genome loci into omnigenic interactome networks from diplotyped sequencing data. Such networks can not only capture dominance, epistasis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Epistasis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Plant

Share to Haplotypes

Share to Models, Genetic

Share to Phenotype

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41915744
DOI: 10.1073/pnas.2600004123
PMCID: PMC13056068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Graph statistics theory of individualized quantitative genetics under haplotype-resolved genome assembly.PMID 41915744Read ↗

Graph-based pangenomics maximizes genotyping density and reveals structural impacts on fungal resistanceSemantic proximity Read ↗

Genomic network analysis characterizes genetic architecture and identifies trait-specific biologySemantic proximity Read ↗

Graph-based pangenomics maximizes genotyping density and reveals structural impacts on fungal resistance in melon.Semantic proximity Read ↗

Graph Pangenomes Track Genetic Variants for Crop Improvement.Semantic proximity Read ↗

Differential Regulation of Cryptic Genetic Variation Shapes the Genetic Interactome Underlying Complex Traits.Semantic proximity Read ↗

The Combined Analysis of Pleiotropy and Epistasis (CAPE).Semantic proximity Read ↗

Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide association summary statistics.Semantic proximity Read ↗

Genetic architecture of naturally occurring quantitative traits in plants: an updated synthesis.Semantic proximity Read ↗

Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures.Semantic proximity Read ↗

The genetic architecture of quantitative traits.Semantic proximity Read ↗

QTLNetwork-MP: integrative mapping of additive, epistatic, and G × E effects for complex traits in multiparent advanced generation intercross populations.Semantic proximity Read ↗

Complex Traits and Candidate Genes: Estimation of Genetic Variance Components Across Modes of InheritanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.