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Article

Amyloid Imaging and APOE Genotype Disclosure and Short-Term Psychological Distress.

JAMA network open - 2 Mar 2026

Grill Joshua D, Raman Rema, Wang Shunran, Ernstrom Karin, Andrews Patricia S, Appleby Brian S, Bhangu Jaspreet, Dhadda Shobha, Irizarry Michael, Johnson Keith, Lenio Steven, MacDonald Steven, Ramanan Vijay K, Rosenberg Paul B, Weisman David, Aisen Paul, Sperling Reisa, Sultzer David, Karlawish Jason

Abstract excerpt

Importance: Alzheimer disease (AD) biomarker and genetic testing results are increasingly disclosed to cognitively unimpaired adults in research and could in the future inform clinical treatment decisions in this population. Objectives: To assess psychological outcomes after returning 3 categories of amyloid biomarker results as well as apolipoprotein E (APOE) genotypes. Design, Setting, and Participants: This...

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Identifiers

PMID: 41910973
DOI: 10.1001/jamanetworkopen.2026.3845
PMCID: PMC13036580

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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