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Article

Impact of learning APOE genotype on cognitively unimpaired adults: a pre-screening cohort study of the Alzheimer's Prevention Initiative Generation Study 1.

The lancet. Healthy longevity - 1 Nov 2025

Langbaum Jessica B, Bradbury Angela R, Egleston Brian L, McCarty Wood Elisabeth, Langlois Carolyn M, Largent Emily A, Harkins Kristin, Erickson Claire M, Stites Shana D, Oyen Emma, Riviere Marie-Emmanuelle, Liu Fonda, Graf Ana, Kim Scott Y H, Grill Joshua D, Reiman Eric M, Tariot Pierre N, Roberts J Scott, Karlawish Jason

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) gene is the best established genetic risk factor for Alzheimer's disease in later life, with the ε4 allele conferring higher risk. APOE disclosure is becoming increasingly common in the clinical care of people with Alzheimer's disease and in cognitively unimpaired adults. In this study, we aimed to describe changes in measures of genetic disease knowledge and psychiatric...

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Identifiers

PMID: 41319675
DOI: 10.1016/j.lanhl.2025.100778
PMCID: PMC12703885

Genes

APOE
GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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