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Article

Disclosing Pleiotropic Effects During Genetic Risk Assessment for Alzheimer Disease: A Randomized Trial.

Annals of internal medicine - 2 Feb 2016

Christensen Kurt D, Roberts J Scott, Whitehouse Peter J, Royal Charmaine D M, Obisesan Thomas O, Cupples L Adrienne, Vernarelli Jacqueline A, Bhatt Deepak L, Linnenbringer Erin, Butson Melissa B, Fasaye Grace-Ann, Uhlmann Wendy R, Hiraki Susan, Wang Na, Cook-Deegan Robert, Green Robert C

Abstract excerpt

BACKGROUND: Increasing use of genetic testing raises questions about disclosing secondary findings, including pleiotropic information. OBJECTIVE: To determine the safety and behavioral effect of disclosing modest associations between apolipoprotein E (APOE) genotype and coronary artery disease (CAD) risk during APOE-based genetic risk assessments for Alzheimer disease (AD). DESIGN: Randomized, multicenter...

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Source

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Identifiers

PMID: 26810768
DOI: 10.7326/M15-0187
PMCID: PMC4979546

Genes

CAD
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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