Article
mRNA BRAF expression helps to identify papillary thyroid carcinomas in thyroid nodules independently of the presence of BRAFV600E mutation.
Pathology, research and practice - 15 Aug 2012
Araujo Priscila Pereira Costa, Marcello Marjory Alana, Tincani Alfio Jose, Guilhen Ana Carolina Trindade, Morari Elaine Cristina, Ward Laura Sterian
Abstract excerpt
Literature has consistently shown associations of BRAFV600E mutation with papillary thyroid cancer clinical features. However, the clinical utility of BRAF expression has not been clinically explored so far. We studied 67 thyroid nodules (32 benign nodules and 35 PTC cases). BRAF mRNA expression levels measured by a quantitative real-time PCR and a PCR-RFLP were used to identify BRAFV600E mutation. BRAF mRNA...
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