UGT1A1 Fragment Analysis: Genotyping the (TA)n Variable Repeat Polymorphism for Clinical Applications.

doi:10.1002/jcla.70214

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Article

UGT1A1 Fragment Analysis: Genotyping the (TA)n Variable Repeat Polymorphism for Clinical Applications.

Journal of clinical laboratory analysis - 1 Jun 2026

Baugher Ryan N, Pike Kristen M, Plona Teri M, Mellott Stephanie D, Young Todd B, Lawhorn Heidi E, Hewitt Stephen M

Abstract excerpt

BACKGROUND: UGT1A1 is involved in glucuronidation of drugs and plays a large role in metabolism. Genotyping variants of differing dinucleotide TA repeat length within the TATA box of the UGT1A1 region (dbSNP ID rs3064744) are utilized in the dosing of irinotecan and atazanavir for pharmacogenomics purposes. Here we describe a CLIA-validated PCR and fragment analysis assay that distinguishes between UGT1A1*36...

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Identifiers

PMID: 41906410
DOI: 10.1002/jcla.70214
PMCID: PMC13327469

Genes

UGT1A1
GC

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