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Article

Comparison of three methods for genotyping the UGT1A1 (TA)n repeat polymorphism.

Clinical biochemistry - 1 Jun 2007

Baudhuin Linnea M, Highsmith W Edward, Skierka Jennifer, Holtegaard Leonard, Moore Brenda E, O'Kane Dennis J

Abstract excerpt

OBJECTIVES: The UGT1A1 promoter contains a (TA)n repeat polymorphism. The 7 repeat allele is associated with decreased enzyme activity and patients homozygous for this allele treated with irinotecan may experience life-threatening toxicity. Here, we have compared three methods [DNA sequencing, fragment analysis, and the Invader assay (Third Wave Technologies)] for genotyping this polymorphism. RESULTS: All of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17459361
DOI: 10.1016/j.clinbiochem.2007.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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