Article
Diverse sources of C. difficile infection identified on whole-genome sequencing.
The New England journal of medicine - 26 Sept 2013
Eyre David W, Cule Madeleine L, Wilson Daniel J, Griffiths David, Vaughan Alison, O'Connor Lily, Ip Camilla L C, Golubchik Tanya, Batty Elizabeth M, Finney John M, Wyllie David H, Didelot Xavier, Piazza Paolo, Bowden Rory, Dingle Kate E, Harding Rosalind M, Crook Derrick W, Wilcox Mark H, Peto Tim E A, Walker A Sarah
Abstract excerpt
BACKGROUND: It has been thought that Clostridium difficile infection is transmitted predominantly within health care settings. However, endemic spread has hampered identification of precise sources of infection and the assessment of the efficacy of interventions. METHODS: From September 2007 through March 2011, we performed whole-genome sequencing on isolates obtained from all symptomatic patients with C....
Topics
- Aged
- Aged, 80 and over
- Clostridioides difficile
- Clostridium Infections
- Cross Infection
- DNA, Bacterial
- Disease Transmission, Infectious
- Female
- Genetic Variation