A Non-Fetal Chronic Residual Inflammatory Liver Phenotype After Transient Abnormal Myelopoiesis in Down Syndrome.

Abstract excerpt

Transient abnormal myelopoiesis (TAM) in Down syndrome (DS) typically causes acute neonatal liver failure; however, late-onset chronic sequelae remain undercharacterized. We report two patients who, despite achieving hematologic remission, developed a persistent non-fatal inflammatory liver phenotype. Unlike the catastrophic neonatal hemochromatosis-like pathway, these cases exhibited sustained transaminase...

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