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Article

The Architecture of Deep Phenotyping in Asthma: Integrating Molecular, Metabolic, and Neuro-Hormonal Endotypes.

International journal of molecular sciences - 10 Mar 2026

Demenciuc Nicolae, Ureche Corina, Budin Corina Eugenia, Stoian Mircea, Nicola-Varo Teodora, Ianosi Edith Simona, Pătrîntașu Dariana-Elena, Goman Anca, Davidescu Lavinia, Deleanu Diana

Abstract excerpt

Asthma is increasingly recognized as a heterogeneous syndrome where traditional management fails, particularly given spirometry's limitations in assessing small airway dysfunction. This review synthesizes the transition from clinical phenotyping to deep molecular endotyping, establishing a framework for precision medicine. We highlight the insufficiency of absolute eosinophil counts, proposing eosinophil cationic...

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Airway Remodeling
Asthma
Biomarkers
Eosinophils
TSLP gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precision Medicine

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PMID: 41898409
DOI: 10.3390/ijms27062545
PMCID: PMC13026805

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TSLP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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