Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.

Abstract excerpt

KRAS serves as a vital regulator for cellular signaling and drives tumor pathogenesis after mutation. Despite extensive research efforts spanning several decades, targeting KRAS is still challenging due to the multiple KRAS mutations and the emergence of drug resistance. Interfering the interactions between KRAS and SOS1 is one of the promising approaches for modulating KRAS functions. Herein, we discovered...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to HeLa Cells
• Share to Indazoles
• Share to Mutation