Article
Joint Associations of Sleep Patterns and Genetic Susceptibility With Dynamic Transitions of Chronic Obstructive Pulmonary Disease and Coronary Heart Disease and the Mediating Role of Inflammatory Biomarkers and Metabolites.
Journal of the American Heart Association - 21 Apr 2026
Zhang Yanyu, Zhu Pingxiu, Gao Darui, Ji Mengmeng, Pan Yang, Dai Yiwen, Liu Yuling, Zheng Fanfan, Xie Wuxiang
Abstract excerpt
BACKGROUND: Sleep behaviors influence the development of chronic obstructive pulmonary disease (COPD) and coronary heart disease (CHD), but their role in the dynamic transitions of COPD and CHD and their interaction with genetic susceptibility on the comorbidity remain unclear. METHODS: Using UK Biobank data, Cox proportional hazard models and multistate survival models were used to examine the associations of...
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