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Article

Considerations for diverse RYR1 variants in malignant hyperthermia susceptible patients: a report of two cases.

BMC anesthesiology - 10 Jun 2026

Fang Yan, Mei Wei, Bi Jiangjiang

Abstract excerpt

Malignant hyperthermia (MH) is an autosomal dominant pharmacogenetic disorder primarily triggered by halogenated volatile anesthetics, succinylcholine, or cisatracurium. This report describes two cases exhibiting typical MH symptoms, including hyperthermia, hypercarbia, tachycardia, and acidosis, but with notable differences in the time of onset and symptom severity. The variable expression of MH may be...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42271251
DOI: 10.1186/s12871-026-04010-8
PMCID: PMC13474918

Genes

RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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