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Activity of Ceftaroline against Enterococcus faecium PBP5

24 Sept 2013

Abstract excerpt

The opportunistic human pathogen Enterococcus faecium overproduces the low-affinity PBP5. In clinical strains, mutations in PBP5 further reduce its acylation rate by β-lactams. Previous studies have reported that ceftaroline had poor inhibitory activity against β-lactam-resistant E. faecium strains. In this study, we show that ceftaroline exhibits killing activity against our laboratory-derived...

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PMID: 24060866
DOI: 10.1128/aac.00923-13

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