Article
Uncoupling of apnea-hypopnea index and oxygen desaturation in als: characterization and diagnostic implications of an "AHI-SpO₂ dissociation" phenotype.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 23 Mar 2026
Li Xueming, Ding Weijiang, Xu Enwang
Abstract excerpt
BACKGROUND: In Amyotrophic Lateral Sclerosis (ALS), sleep-disordered breathing (SDB) is primarily driven by neuromuscular hypoventilation. Traditional metrics like the Apnea-Hypopnea Index (AHI) may therefore lack sensitivity. This study aimed to characterize an “AHI-SpO₂ Dissociation” phenotype—low event frequency despite significant desaturation—and explore its associations. METHODS: We retrospectively analyzed...
Topics
- Humans
- Amyotrophic Lateral Sclerosis
- Polysomnography
- Female
- Retrospective Studies
- Male
- Sleep Apnea Syndromes
- Phenotype
- Aged
- Middle Aged