Sleep phenotypes and respiratory disturbances in spinal muscular atrophy: A systematic review of clinical evidence.

doi:10.1016/j.sleep.2026.108933

Article

Sleep phenotypes and respiratory disturbances in spinal muscular atrophy: A systematic review of clinical evidence.

Sleep medicine - 1 Jul 2026

Gnazzo Martina, Baldini Valentina, Varallo Giorgia, Pisanò Giulia, Biscarini Francesco, Carotenuto Marco, Pizza Fabio, Fiorillo Andrea, Pera Maria Carmela, Plazzi Giuseppe

Abstract excerpt

BACKGROUND: 5q Spinal Muscular Atrophy (SMA) is a rare neuromuscular disorder in which sleep-related respiratory disturbances are common and may worsen morbidity and quality of life. However, systematic evidence on sleep architecture, sleep-disordered breathing (SDB), and treatment outcomes in SM...

Topics

Humans
Phenotype
Muscular Atrophy, Spinal
Sleep Apnea Syndromes
Noninvasive Ventilation

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