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Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair

23 Dec 2016

Abstract excerpt

Abstract BACKGROUND Unraveling the molecular mechanisms that regulate the biology of metastasis-competent circulating tumor cells (CTCs) is urgently needed to understand metastasis formation and tumor relapse. Our group previously established the first cell line (CTC-MCC-41) derived from metastasis-competent CTCs of a patient with colon cancer. METHODS In this study, we analyzed the transcriptome of CTC-MCC-41...

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PMID: 28007957
DOI: 10.1373/clinchem.2016.263582

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