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Article

Plasma level of human epididymis protein 4 is associated with risk of future venous thromboembolism-the Trøndelag Health study.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2026

Cathro Celina Janene, Wulff Eilertsen Ellen-Sofie, Nøst Therese H, Hindberg Kristian D, Tang Weihong, Guan Weihua, Folsom Aaron R, Jonasson Christian, Thomas Laurent, Hveem Kristian, Brækkan Sigrid K, Hansen John-Bjarne

Abstract excerpt

BACKGROUND: Plasma human epididymis protein 4 (HE4) levels have been associated with the risk of future venous thromboembolism (VTE) in a proteome-wide study. OBJECTIVES: We aimed to investigate whether plasma HE4 levels were (i) correlated with growth differentiation factor-15 (GDF-15), a marker of oxidative stress, (ii) associated with VTE risk after adjustment for potential confounders, and (iii) genetically...

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Identifiers

PMID: 41862097
DOI: 10.1016/j.jtha.2026.03.009
PMCID: PMC13486973

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