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Article

Elevated plasma concentration of complement factor C5 is associated with risk of future venous thromboembolism.

Blood - 25 Nov 2021

Skjeflo Espen Waage, Brækkan Sigrid Kufaas, Ludviksen Judith Krey, Snir Omri, Hindberg Kristian, Mollnes Tom Eirik, Hansen John-Bjarne

Abstract excerpt

The role of complement in the pathogenesis of venous thromboembolism (VTE) is unclear. We wanted to investigate (1) whether plasma complement component C5 (C5) levels are influenced by genetic variants or chronic inflammation and (2) the association between plasma C5 and risk of future VTE in a nested case-control study of 415 patients with VTE and 848 age- and sex-matched controls derived from the Tromsø Study....

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PMID: 34339498
DOI: 10.1182/blood.2021010822

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