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Genetically predicted mannose-binding lectin levels and risk of future venous thromboembolism-the HUNT Study.

Journal of thrombosis and haemostasis : JTH - 1 May 2026

Damoah Christabel Esi, Tøndel Birgitte, Snir Omri, Garred Peter, Mollnes Tom Eirik, Hveem Kristian, Grover Steven P, Hindberg Kristian Dalsbø, Brækkan Sigrid K, Hansen John-Bjarne

Abstract excerpt

BACKGROUND: Elevated plasma mannose-binding lectin (MBL) levels are associated with increased risk of venous thromboembolism (VTE). Although MBL levels are affected by environmental factors, it is mainly genetically regulated. OBJECTIVES: We aimed to investigate the association between genetically predicted MBL and VTE risk in a population-based cohort. METHODS: The study comprised 68 999 individuals from the...

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PMID: 41692088
DOI: 10.1016/j.jtha.2026.01.028

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