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Article

Evaluating ancestry adjustment in multi-ancestry epigenome-wide analysis.

Epigenetics - 31 Dec 2026

Liu Yueming, Kuang Alan, Hivert Marie-France, Lowe William L, Josefson Jami L, Scholtens Denise M

Abstract excerpt

Proper adjustment for population substructure is essential in epigenome-wide association studies (EWAS), particularly in cohorts with diverse ancestries. EPISTRUCTURE offers a genotype-free approach to ancestry inference, originally developed using a European reference population from the Cooperative Health Research in the Region of Augsburg (KORA) study. However, its effectiveness in genetically diverse,...

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PMID: 41859971
DOI: 10.1080/15592294.2026.2646063

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