Article
Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations.
International journal of obesity (2005) - 1 Feb 2017
Yoneyama S, Yao J, Guo X, Fernandez-Rhodes L, Lim U, Boston J, Buzková P, Carlson C S, Cheng I, Cochran B, Cooper R, Ehret G, Fornage M, Gong J, Gross M, Gu C C, Haessler J, Haiman C A, Henderson B, Hindorff L A, Houston D, Irvin M R, Jackson R, Kuller L, Leppert M, Lewis C E, Li R, Le Marchand L, Matise T C, Nguyen K-Dh, Chakravarti A, Pankow J S, Pankratz N, Pooler L, Ritchie M D, Bien S A, Wassel C L, Chen Y-D I, Taylor K D, Allison M, Rotter J I, Schreiner P J, Schumacher F, Wilkens L, Boerwinkle E, Kooperberg C, Peters U, Buyske S, Graff M, North K E
Abstract excerpt
BACKGROUND/OBJECTIVES: Central adiposity measures such as waist circumference (WC) and waist-to-hip ratio (WHR) are associated with cardiometabolic disorders independently of body mass index (BMI) and are gaining clinically utility. Several studies report genetic variants associated with central adiposity, but most utilize only European ancestry populations. Understanding whether the genetic associations...
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