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A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein translation

2022-10-07

Abstract excerpt

Progeria syndromes are very rare, incurable premature aging conditions recapitulating most aging features. Here, we report the first whole genome, multiparametric CRISPR anti-aging screen, identifying 43 new genes that can reverse multiple aging phenotypes in progeria. The screen was implemented in fibroblasts from Néstor- Guillermo Progeria Syndrome (NGPS) patients, carrying a homozygous p.Ala12Thr mutation in ba...

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Literature Corpus work
38ca2318-acb5-5017-8872-03c39fd3486e
DOI
10.1101/2022.10.07.509469
Open publication

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A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein translationDOI 10.1101/2022.10.07.509469
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