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Article

PCSK9 Inhibitors and Bipolar Disorder: A Drug Target Mendelian Randomization Study.

Clinical neuropharmacology - 1 Jan 2026

Li Jin, Yao Pei-Sen

Abstract excerpt

OBJECTIVE: Bipolar disorder (BD) patients remain symptomatic. As lipid-lowering drug targets have been linked to BD risk, we used Mendelian randomization (MR) to assess their therapeutic potential. METHODS: We conducted MR analyses utilizing genetic variants associated with lipid traits and variants in genes encoding the protein targets of various classes of lipid-lowering drugs. The specific drug classes...

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Share to Bipolar Disorder
Share to Cholesterol, LDL
Share to HMGCR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PGC gene

Share to Membrane Transport Proteins

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Proprotein Convertase 9

Source

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Identifiers

PMID: 41855073
DOI: 10.1097/WNF.0000000000000677
PMCID: PMC13166066

Genes

PCSK9
HMGCR
NPC1L1
PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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