Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of HFE gene mutation and iron overload on sustained virological response in Egyptian chronic hepatitis C patients treated with daclatasvir and sofosbuvir.

The Korean journal of internal medicine - 1 Mar 2026

Kodsi Emad M, Ismail Hisham, Issa Randa, Elshaarawy Ahmed, Sakr Moustafa A, Shehata Eman L, Issak Emad R

Abstract excerpt

BACKGROUND/AIMS: This matched case-control study investigated the impact of HFE gene mutations on sustained virological response (SVR) in Egyptian patients with chronic hepatitis C (CHC) treated with daclatasvir and sofosbuvir. METHODS: A total of 150 CHC patients were enrolled (75 responders and 75 non-responders) based on HCV RNA levels 12 weeks post-treatment. HFE gene mutations (C282Y, H63D, S65C) were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbamates
Share to Egypt

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferritins

Share to Hemochromatosis Protein

Share to Iron Overload

Share to Pyrrolidines

Share to Sofosbuvir

Share to Sustained Virologic Response

Source

Open in PubMed Open full text

Identifiers

PMID: 41850218
DOI: 10.3904/kjim.2025.156
PMCID: PMC12999251

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of HFE gene mutation and iron overload on sustained virological response in Egyptian chronic hepatitis C patients treated with daclatasvir and sofosbuvir.PMID 41850218Read ↗

HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis.Semantic proximity Read ↗

Significance of Hereditary Hemochromatosis Gene (HFE) Mutations in Chronic Hepatitis C and Hepatocellular Carcinoma Patients in Egypt: A Pilot Study.Semantic proximity Read ↗

The role of iron overload and HFE gene mutations in the era of pegylated interferon and ribavirin treatment of chronic hepatitis C.Semantic proximity Read ↗

Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C.Semantic proximity Read ↗

Clinical impact of HFE mutations in Japanese patients with chronic hepatitis C.Semantic proximity Read ↗

The H63D genetic variant of the HFE gene is independently associated with the virological response to interferon and ribavirin therapy in chronic hepatitis C.Semantic proximity Read ↗

Hepatitis C, iron status, and disease severity: relationship with HFE mutations.Semantic proximity Read ↗

Non-HFE iron overload as a surrogate marker of disease severity in patients of liver cirrhosis.Semantic proximity Read ↗

Effect of HFE gene polymorphism on sustained virological response in patients with chronic hepatitis C and elevated serum ferritin.Semantic proximity Read ↗

Hepatic iron overload in patients with chronic viral hepatitis: role of HFE gene mutations.Semantic proximity Read ↗

Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: impact on iron status, liver injury and HCV genotype.Semantic proximity Read ↗

Mutant HFE genotype leads to significant iron overload in patients with liver diseases from western Romania.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.