Article
Topological stratification of continuous genetic variation in large biobanks.
PLoS genetics - 1 Mar 2026
Diaz-Papkovich Alex, Zabad Shadi, Snell Hannah, Ben-Eghan Chief, Anderson-Trocmé Luke, Femerling Georgette, Nathan Vikram, Patel Jenisha, Gravel Simon
Abstract excerpt
Biobanks now contain genetic data from millions of individuals. Dimensionality reduction, visualization and clustering are standard when exploring data at these scales; while efficient and tractable methods exist for the first two, clustering remains challenging because of the many ways in which demography and sampling can affect structure. In practice, clustering is commonly performed by drawing shapes around...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
