Article

Revealing multi-scale population structure in large cohorts

2018-09-23

Abstract excerpt

Genetic structure in large cohorts results from technical, sampling and demographic variation. Visualisation is therefore a first step in most genomic analyses. However, existing data exploration methods struggle with unbalanced sampling and the many scales of population structure. We investigate an approach to dimension reduction of genomic data that combines principal components analysis (PCA) with uniform manif...

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Literature Corpus work: f90809ec-4399-5f64-8377-f61b2b375d9d
DOI: 10.1101/423632

Open publication

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