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Article

Genetic regulation of AIF1 shapes immune and liver injury profiles in chronic alcohol use.

JCI insight - 22 Apr 2026

Antonello Priscila C, Hodgkinson Colin A, Feng Dechun, Marietta Cheryl, Mohana Krishnan Baskar, Parra Maria A, Sun Zhaoli, Gao Bin, Goldman David, Antoine Michelle W

Abstract excerpt

BACKGROUNDIn chronic alcohol consumers, immune cells may drive the progression from mild liver injury to more severe alcohol-associated liver disease (ALD), including alcohol-associated hepatitis (AAH) and cancer. Liver macrophages, both resident and infiltrating, express allograft inflammatory factor 1 (AIF1), which is upregulated during inflammation and enhances immune activation.METHODSUsing serum and urine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Liver Diseases, Alcoholic

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Source

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Identifiers

PMID: 41838574
DOI: 10.1172/jci.insight.198209
PMCID: PMC13135398

Genes

AIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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