Article
Scalable high resolution ancestry deconvolution for genomic data.
Nature communications - 25 Jul 2026
Hilmarsson Helgi, Kumar Arvind S, Barrabés Míriam, Rastogi Richa, Bustamante Carlos D, Montserrat Daniel Mas, Ioannidis Alexander G
Abstract excerpt
As genome-wide association studies and genetic risk prediction models extend to globally diverse and admixed biobanks, accurate, scalable ancestry deconvolution, also called local ancestry inference (LAI), has become crucial. LAI assigns ancestry to each genomic segment within an individual, enabling studies of population history and ancestry-associated haplotypic effects. Existing LAI methods scale poorly to...
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