Article
Precision management of medullary thyroid carcinoma: a dynamic framework integrating biomarkers, genotyping, and risk stratification.
Frontiers in endocrinology - 1 Jan 2026
Jia Chengzheng, Guo Shaohua, Wu Kehui, Wang Yaoqi, Yang Shuai, Wang Lei, Chen Tianyu, Meng Xianying
Abstract excerpt
Medullary thyroid carcinoma (MTC) is a heterogeneous neuroendocrine malignancy in which outcomes are shaped by tumor burden, locoregional spread, and molecular context. Precision management therefore requires explicit separation of hereditary MTC driven by germline RET variants from presumed sporadic disease, and a structured integration of serum biomarkers, imaging, pathology, and genotype. This review...
Topics
- Humans
- Thyroid Neoplasms
- Biomarkers, Tumor
- Carcinoma, Neuroendocrine
- Precision Medicine
- Risk Assessment
- Genotype
- Proto-Oncogene Proteins c-ret
- Germ-Line Mutation