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Article

Angiogenin mediates paternal inflammation-induced metabolic disorders in offspring through sperm tsRNAs.

Nature communications - 29 Nov 2021

Zhang Yanwen, Ren Li, Sun Xiaoxiao, Zhang Zhilong, Liu Jie, Xin Yining, Yu Jianmin, Jia Yimin, Sheng Jinghao, Hu Guo-Fu, Zhao Ruqian, He Bin

Abstract excerpt

Paternal environmental inputs can influence various phenotypes in offspring, presenting tremendous implications for basic biology and public health and policy. However, which signals function as a nexus to transmit paternal environmental inputs to offspring remains unclear. Here we show that offspring of fathers with inflammation exhibit metabolic disorders including glucose intolerance and obesity. Deletion of a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34845238
DOI: 10.1038/s41467-021-26909-1
PMCID: PMC8630171

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