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Article

An integrative framework for drug target discovery bridging clinical trial and genetic data insights.

Journal of translational medicine - 13 Mar 2026

Mielke Johanna, Strunz Tobias, Lee Jeongah, Schloemer Patrick, Gallone Giuseppe

Abstract excerpt

BACKGROUND: Over the past few years, the considerable growth in the availability of population-scale genomic data has provided a significant boost in supporting quantitative, well powered, data-driven approaches to drug target discovery. However, population-scale genomic biobanks often lack comprehensive longitudinal phenotyping and in-depth clinical annotation. In contrast, clinical trial data, rich in...

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PMID: 41827014
DOI: 10.1186/s12967-026-07806-x
PMCID: PMC12994227

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