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Article

Erythropoietin drug targets and cancer risk: A two-sample Mendelian randomization study.

Medicine - 13 Mar 2026

Chen Hailing, Yang Xuefei, Huang Ting, Zhou Heran

Abstract excerpt

Erythropoiesis-stimulating agents (ESAs) are widely used to treat anemia, but their on-target effects on tumor risk via erythropoietin (EPO)/erythropoietin receptor (EPOR) signaling remain debated. This study aims to evaluate the potential causal relationship between EPO signaling and the risk of 14 site-specific cancers using a drug-target Mendelian randomization (MR) approach. We proxied EPO signaling using...

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Source

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Identifiers

PMID: 41824808
DOI: 10.1097/MD.0000000000048078
PMCID: PMC12991644

Genes

EPO
EPOR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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