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Article

ctDNA and tumor-based biomarkers of giredestrant response in acelERA breast cancer.

Nature communications - 12 Mar 2026

Collier Ann E, Hilz Stephanie, Chibly Alejandro M, Duan Chunzhe, Pasquina Lincoln W, Sun Xiaopeng, Chavez-MacGregor Mariana, Bardia Aditya, Martín Miguel, Lim Elgene, Sohn Joohyuk, Pérez-Moreno Pablo Diego, Fernando Tharu M, Moore Heather M

Abstract excerpt

Endocrine therapy (ET) resistance in estrogen receptor positive (ER+) advanced breast cancer is often linked to ESR1 mutations, yet responses to oral selective ER degraders vary within mutant subgroups. Through a biomarker analysis of acelERA Breast Cancer (NCT04576455), we show that tumor ER transcriptional activity as well as circulating tumor DNA (ctDNA) genomics and dynamics effectively stratify response to...

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Share to Antineoplastic Agents, Hormonal
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Circulating Tumor DNA

Share to Drug Resistance, Neoplasm

Share to Estrogen Receptor alpha

Share to CDK4 gene

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Source

Open in PubMed Open full text

Identifiers

PMID: 41820395
DOI: 10.1038/s41467-026-70335-0
PMCID: PMC13121440

Genes

ESR1
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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