Article
Diagnostic yield of multigene panel testing in an Israeli cohort: enrichment of low-penetrance variants.
Breast cancer research and treatment - 1 Jun 2020
Bernstein-Molho Rinat, Friedman Eitan, Kedar Inbal, Laitman Yael, Allweis Tanir M, Gal-Yam Einav Nili, Feldman Hagit Baris, Grinshpun Albert, Halpern Naama, Hartmajer Shulamit, Kadouri Luna, Katz Lior H, Kaufman Bella, Laish Ido, Levanon Keren, Philipsborn Shira Litz, Ludman Mark, Moran Gal, Peretz Tamar, Reinstein Eyal, Levi Gili Reznick, Safra Tamar, Shkedi Shiri, Vinkler Chana, Levy Zohar, Goldberg Yael
Abstract excerpt
BACKGROUND: Carriers of pathogenic variants (PVs) in moderate-high-penetrance cancer susceptibility genes are offered tailored surveillance schemes for early cancer diagnosis. The clinical implications of low-penetrance variant carriers are less clear. METHODS: Clinical and demographic data were retrieved for a cohort of Israeli individuals who underwent oncogenetic testing by the 30-gene cancer panel at Color...
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