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Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer's disease PSEN1 p.M146L patient.

Stem cell research - 1 Jun 2026

Vautier Mercedes Florencia, Chrem Mendez Patricio, Jerez Ferreyra Guillermo, Massazza Victoria, Apecetche Manuela, Rodríguez Varela María Soledad, Clas Giulia, Nievas Micaela, Allegri Ricardo, Sevlever Gustavo Emilio, Scassa María Elida, Surace Ezequiel Ignacio, Marazita Mariela Claudia, Romorini Leonardo

Abstract excerpt

Human induced pluripotent stem cell (hiPSC) line FLENIi004-A was generated from peripheral blood mononuclear cells (PBMCs) using the lentiviral-hSTEMCCA-loxP vector. FLENIi004-A was derived from a 41-year-old Argentinean Caucasian male patient with Autosomal-Dominant Alzheimer's Disease, who carried the heterozygous PSEN1 p.M146L mutation. The hiPSC line retained the PSEN1 mutation, and its pluripotency and...

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Identifiers

PMID: 41819741
DOI: 10.1016/j.scr.2026.103958

Genes

PSEN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Generation of a human induced pluripotent stem cell line (FLENIi004-A) from an Autosomal-Dominant Alzheimer's disease PSEN1 p.M146L patient.PMID 41819741Read ↗

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