Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of epigenetic regulatory genes are common in thymic carcinomas.

Scientific reports - 8 Dec 2014

Wang Yisong, Thomas Anish, Lau Christopher, Rajan Arun, Zhu Yuelin, Killian J Keith, Petrini Iacopo, Pham Trung, Morrow Betsy, Zhong Xiaogang, Meltzer Paul S, Giaccone Giuseppe

Abstract excerpt

Genetic alterations and etiology of thymic epithelial tumors (TETs) are largely unknown, hampering the development of effective targeted therapies for patients with TETs. Here TETs of advanced-stage patients enrolled in a clinical trial of molecularly-guided targeted therapies were employed for targeted sequencing of 197 cancer-associated genes. Comparative sequence analysis of 78 TET/blood paired samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation Rate

Share to Neoplasm Grading

Share to Neoplasm Staging

Share to Neoplasms, Glandular and Epithelial

Share to Thymus Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25482724
DOI: 10.1038/srep07336
PMCID: PMC4258655

Genes

ASXL1
BAP1
SETD2
SMARCA4
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of epigenetic regulatory genes are common in thymic carcinomas.PMID 25482724Read ↗

The Molecular Landscape of Thymic Epithelial Tumors: A Comprehensive ReviewSemantic proximity Read ↗

Integrated Molecular and Clinical Analysis of Thymic Epithelial Tumors.Semantic proximity Read ↗

Somatic and germline genomic variation in thymic carcinomas.Semantic proximity Read ↗

Genomic characterization of thymic epithelial tumors in a real-world datasetSemantic proximity Read ↗

Characteristics of Genomic Mutations and Signaling Pathway Alterations in Thymic Epithelial TumorsSemantic proximity Read ↗

Molecular landscape of thymic epithelial tumors.Semantic proximity Read ↗

Epigenetics of Thymic Epithelial TumorsSemantic proximity Read ↗

Genomic landscape and molecularly informed therapy in thymic carcinoma and other advanced thymic epithelial tumors.Semantic proximity Read ↗

The genomic and epigenomic landscape in thymic carcinoma.Semantic proximity Read ↗

Genetic insights into thymic carcinomas and thymic neuroendocrine neoplasms denote prognosis signatures and pathways.Semantic proximity Read ↗

Targeted Next-Generation Sequencing of Thymic Epithelial Tumours Revealed Pathogenic Variants in KIT, ERBB2, KRAS, and TP53 in 30% of Thymic CarcinomasSemantic proximity Read ↗

Identification of novel mutations of TP53, ALK and RET gene in metastatic thymic squamous cell carcinoma and its therapeutic implication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.