Article
Genome-Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology.
Movement disorders : official journal of the Movement Disorder Society - 1 May 2026
Step Kathryn, Hernández Carlos F, Khani Marzieh, Eltaraifee Esraa, Hernández-Medrano Ana Jimena, Kung Pin-Jui, Ostrožovičová Miriam, Zirra Alexandra, Pérez-Palma Eduardo, Mencacci Niccolò E, Keller Sarmiento Ignacio J, Morris Huw R, Mata Ignacio F, Acosta-Uribe Juliana, Fang Zih-Hua, Bandres-Ciga Sara
Abstract excerpt
BACKGROUND: Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. OBJECTIVE: We conducted the first large-scale, multi-ancestral investigation of PD to examine the impact of genome-wide homozygosity on disease risk and age at onset (AAO). Using genotyping, imputed, and...
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