Evidence of phenotypes indexing cognitive resilience and vulnerability in the early course of mood and psychosis spectrum illness; mapping the latent structure, characteristics, and longitudinal stability of cognitive heterogeneity.

doi:10.1016/j.euroneuro.2026.112800

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Article

Evidence of phenotypes indexing cognitive resilience and vulnerability in the early course of mood and psychosis spectrum illness; mapping the latent structure, characteristics, and longitudinal stability of cognitive heterogeneity.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jun 2026

Van Rheenen Tamsyn E, Ringin Elysha, Meyer Denny, Allott Kelly, Wenzel Julian, Upthegrove Rachel, Stainton Alexandra, Salokangas Raimo K R, Ruhrmann Stephan, Rosen Marlene, Meisenzahl Eva, Maggioni Eleonora, Lichtenstein Theresa, Lencer Rebekka, Kambeitz Joseph, Dannlowski Udo, Dwyer Dominic B, Chisholm Katie, Borgwardt Stefan, Bonivento Carolina, Bertolino Alessandro, Antonucci Linda, Koutsouleris Nikolaos, Brambilla Paolo, Pantelis Christos, Kambeitz-Ilankovic Lana, Wood Stephen J

Abstract excerpt

The latent structure and longitudinal stability of cognitive heterogeneity during the early course of mood and psychosis spectrum illness has not been well-studied. We determined the presence, stability and characteristics of latent cognitive profiles underlying a transdiagnostic sample of individuals at high risk for psychosis (CHR) or with a recent onset of psychosis (ROP) or depression (ROD). The sample...

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PMID: 41807908
DOI: 10.1016/j.euroneuro.2026.112800

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