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Novel genetic insights: Mendelian randomization implicates Felty Syndrome in atrial fibrillation risk.

Clinical rheumatology - 1 May 2026

Du Ruijuan, Zhang Yanlong, Cheng Fei, Ge Guoqing, Fan Yanming

Abstract excerpt

OBJECTIVES: Atrial fibrillation (AF) is a common and increasing arrhythmia posing major public health challenges. While management has improved, long-term efficacy and safety remain limited. Felty Syndrome, a severe rheumatoid arthritis (RA) subtype with splenomegaly and neutropenia, offers a chance to examine the autoimmune inflammation-AF link. METHOD: We employed five Mendelian randomization (MR) approaches...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41807677
DOI: 10.1007/s10067-026-08031-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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