Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional study of two flexible regions of the hepatitis E virus ORF1 replicase.

PloS one - 1 Jan 2026

Mézière Léa, Fieulaine Sonia, Montpellier Claire, Ferrié Martin, Tubiana Thibault, Vanegas Arias Gabriel, Bressanelli Stéphane, Cocquerel Laurence, Aliouat-Denis Cécile-Marie

Abstract excerpt

Hepatitis E virus (HEV), like other positive-sense RNA viruses, encodes a multidomain protein essential for replication, termed ORF1. However, the number, organization, and functions of its domains remain debated. Using AlphaFold2-based structural modeling, we investigated two structurally disordered regions with potential regulatory functions: (i) a 16-residue linker between the Helicase (Hel) and RNA-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Hepatitis E virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Open Reading Frames

Share to Protein Domains

Share to RNA-Dependent RNA Polymerase

Share to Viral Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 41805850
DOI: 10.1371/journal.pone.0343555
PMCID: PMC12974834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional study of two flexible regions of the hepatitis E virus ORF1 replicase.PMID 41805850Read ↗

Proteasomal processing of the viral replicase ORF1 facilitates HEV-induced liver fibrosisSemantic proximity Read ↗

The hepatitis E virus nonstructural polyprotein.Semantic proximity Read ↗

Hepatitis E Virus ReplicationSemantic proximity Read ↗

An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cellSemantic proximity Read ↗

Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replicationSemantic proximity Read ↗

The Hepatitis E Virus Open Reading Frame 2 Protein: Beyond Viral CapsidSemantic proximity Read ↗

The hepatitis E virus capsid protein ORF2 counteracts cell-intrinsic antiviral responses to enable persistence in hepatocytesSemantic proximity Read ↗

Hepatitis E virus RNA-dependent RNA polymerase is involved in RNA replication and infectious particle production.Semantic proximity Read ↗

An Arginine-Rich Motif in the ORF2 Capsid Protein Regulates the Hepatitis E Virus Lifecycle and Interactions with the Host CellSemantic proximity Read ↗

Early secretory pathway localization and lack of processing for hepatitis E virus replication protein pORF1Semantic proximity Read ↗

Interaction of Host Cellular Proteins with Components of the Hepatitis Delta VirusSemantic proximity Read ↗

Interdomain Flexibility of Chikungunya Virus nsP2 Helicase-Protease Differentially Influences Viral RNA Replication and Infectivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.