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The Hepatitis E Virus Open Reading Frame 2 Protein: Beyond Viral Capsid

7 Oct 2021

Abstract excerpt

Hepatitis E virus (HEV) is a zoonotic pathogen causing hepatitis in both human and animal hosts, which is responsible for acute hepatitis E outbreaks worldwide. The 7.2 kb genome of the HEV encodes three well-defined open reading frames (ORFs), where the ORF2 translation product acts as the major virion component to form the viral capsid. In recent years, besides forming the capsid, more functions have been...

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PMID: 34690982
DOI: 10.3389/fmicb.2021.739124

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