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Article

Uncovering pleiotropic loci linking keratoconus and allergic diseases through integrative genomic analyses.

Scientific reports - 12 Jan 2026

Li Gangyi, Wang Yuke, Xiao Yizhi, Li Shuangle

Abstract excerpt

Keratoconus (KC) is a progressive corneal disease increasingly linked to immune dysregulation. Epidemiological studies have suggested comorbidity between KC and allergic diseases such as atopic dermatitis (AD), allergic conjunctivitis (AC), allergic rhinitis (AR), and allergic asthma (AA), yet their shared genetic mechanisms remain unclear. To investigate the shared genetic architecture between KC and four common...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41526633
DOI: 10.1038/s41598-025-34146-5
PMCID: PMC12855181

Genes

AR
GATA3
IL18R1
KLF5
SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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