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Article

SPICE-GRADE: simultaneous processing of indirect causal evidence in complex pathways using GRADE - an exploratory case study.

Journal of clinical epidemiology - 1 Jun 2026

Eachempati Prashanti, Guyatt Gordon, Vandvik Per Olav, Guerin Philippe J, Dahal Prabin, Barnes Karen I, Agoritsas Thomas

Abstract excerpt

BACKGROUND AND OBJECTIVES: Genetic mutations often result in antimicrobial resistance. Early identification of emerging resistance due to genetic mutations often relies on multiple coexisting pathways of indirect evidence. The GRADE approach, widely used to rate certainty in treatment comparisons, offers little guidance to address such situations. Motivated by the possibility of emerging resistance to malaria, we...

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PMID: 41802581
DOI: 10.1016/j.jclinepi.2026.112219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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