Article
Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2017
Ataide Ricardo, Ashley Elizabeth A, Powell Rosanna, Chan Jo-Anne, Malloy Michael J, O'Flaherty Katherine, Takashima Eizo, Langer Christine, Tsuboi Takafumi, Dondorp Arjen M, Day Nicholas P, Dhorda Mehul, Fairhurst Rick M, Lim Pharath, Amaratunga Chanaki, Pukrittayakamee Sasithon, Hien Tran Tinh, Htut Ye, Mayxay Mayfong, Faiz M Abul, Beeson James G, Nosten Francois, Simpson Julie A, White Nicholas J, Fowkes Freya J I
Abstract excerpt
Artemisinin-resistant falciparum malaria, defined by a slow-clearance phenotype and the presence of kelch13 mutants, has emerged in the Greater Mekong Subregion. Naturally acquired immunity to malaria clears parasites independent of antimalarial drugs. We hypothesized that between- and within-population variations in host immunity influence parasite clearance after artemisinin treatment and the interpretation of...
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