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Establishment and characterization of NCC-GCTB10-C1: a novel cell line derived from a patient with recurrent giant cell tumor of bone.

Human cell - 9 Dec 2024

Adachi Yuki, Noguchi Rei, Osaki Julia, Ono Takuya, Akiyama Taro, Kondo Hiroya, Kobayashi Eisuke, Kojima Naoki, Yoshida Akihiko, Yokoo Hideki, Kawai Akira, Kondo Tadashi

Abstract excerpt

Giant cell tumor of bone (GCTB) is a rare osteolytic tumor composed of mononuclear stromal cells, macrophages, and osteoclast-like giant cells. While generally benign, GCTB has a high risk of local recurrence and can occasionally undergo malignant transformation or metastasis, posing significant clinical challenges. The primary treatment is complete surgical resection; however, effective management strategies for...

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PMID: 39653987
DOI: 10.1007/s13577-024-01153-z

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